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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME - USD ($)
shares in Millions, $ in Millions
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Revenues:      
Revenue from contract with customer $ 13,117.2 $ 12,172.9 $ 16,071.7 Close
Expenses:      
Research and development 4,439.0 3,592.5 2,860.1
Acquired in-process research and development 186.1 255.1 48.0
Selling, general, and administrative 2,631.3 2,115.9 1,824.9
Other operating (income) expense, net (2.1) (89.9) (45.6)
Total expenses 9,070.1 7,434.0 7,124.9 Close
Income from operations 4,047.1 4,738.9 8,946.8 Close
Other income (expense):      
Other income (expense), net 225.2 179.3 436.3
Interest expense (73.0) (59.4) (57.3)
Total other income (expense) 152.2 119.9 379.0 Close
Income before income taxes 4,199.3 4,858.8 9,325.8 Close
Income tax expense 245.7 520.4 1,250.5 Close
Net income $ 3,953.6 $ 4,338.4 $ 8,075.3 Close
Net income per share - basic (in dollars per share) $ 37.05 $ 40.51 $ 76.40
Net income per share - diluted (in dollars per share) $ 34.77 $ 38.22 $ 71.97
Weighted average shares outstanding - basic (in shares) 106.7 107.1 105.7
Weighted average shares outstanding - diluted (in shares) 113.7 113.5 112.2
Statements of Comprehensive Income      
Net income $ 3,953.6 $ 4,338.4 $ 8,075.3
Other comprehensive income (loss), net of tax:      
Unrealized gain (loss) on debt securities 158.2 (213.6) (56.4)
Loss on foreign currency translation (0.3) 0.0 0.0
Unrealized gain on cash flow hedges 0.0 1.0 0.9
Comprehensive income 4,111.5 4,125.8 8,019.8
Net product sales      
Revenues:      
Revenue from contract with customer 7,078.0 6,893.7 12,117.2
Expenses:      
Cost of goods sold and of collaboration and contract manufacturing 932.1 800.0 1,773.1
Collaboration revenue      
Revenues:      
Revenue from contract with customer 5,503.1 4,914.1 3,673.3
Other revenue      
Revenues:      
Revenue from contract with customer 536.1 365.1 281.2
Cost of collaboration and contract manufacturing      
Expenses:      
Cost of goods sold and of collaboration and contract manufacturing $ 883.7 $ 760.4 $ 664.4